Intracranial Recording Front Ends

Nano 2

  • For high-impedance microelectrodes
  • Lightweight for small animal studies
  • 19.5 mm x 15.5 mm x 4 mm
  • 2.0 grams
nano2

Micro 2

  • For high-impedance microelectrodes
  • 40 mm x 32 mm x 4.75 mm
  • 9.0 grams
micro2

Gather precise recordings from up to 32 high-impedance microelectrodes

Integrated filtering, amplification, and 16-bit digitization for high-fidelity signal acquisition

Two independent references (configurable with manual switches)

Independent impedance measuring ability on each channel

The Nano 2 and Micro 2 Front Ends meet safety and electrical isolation standards for use with human subjects under IDE or university IRB approval

Primary Use Cases

  • Single/multi-unit activity
  • LFP
  • ECoG

Specifications

Recording – Single Selectable Reference
Resolution 16-bit – 0.125, 0.25, or 0.5 μV/bit (programmable)
Input Range ± 4, 8, or 12 mV (set by resolution)
Sampling Frequency 30 ksps
Hardware Filtering 0.1 – 100 Hz HPF (programmable), 7.5 kHz LPF
Impedance Measurement 10 kΩ to 1.0 MΩ
Input – Referred Noise < 2.1 μVrms

Stimulation & Recording Front Ends

Nano 2+Stim

  • For high-impedance microelectrodes
  • Lightweight for small animal studies
  • 26.5 mm x 21.5 mm x 4 mm
  • 3.5 grams
nano_2__stim

Micro 2+Stim

  • For high-impedance microelectrodes
  • Metal case for enhanced ESD protection
  • 40 mm x 32 mm x 4.75 mm
  • 9.5 grams
product-micro2stim

32 Channels of Simultaneous Recording and Stimulation

Advanced circuitry enables complex stimulation patterns

Fast-settle feature allows for stimulus artifact rejection and rapid recording recovery following stimulation

The Micro 2+Stim and Nano 2+Stim meet relevant safety and electrical isolation standards for use with human subjects, under IDE or university IRB

Primary Use Cases

  • Stimulation
  • Single/multi-unit activity
  • LFP
  • ECoG

Specifications

Recording
Resolution 16-bit – 0.125, 0.25, or 0.5 μV/bit (programmable)
Input Range ± 4, 8, or 12 mV (set by resolution)
Sampling Frequency 30 ksps
Hardware Filtering 1.0 Hz HPF, 7.5 kHz LPF
Impedance Measurement 10 kΩ to 400 kΩ electrodes
Input – Referred Noise < 2.1 μVrms
Recording Recovery Post Stimulation < 1 ms
Current-Controlled Stimulation
Resolution 1, 2, 5, 10, or 20 μA/step (programmable)
Stimulation Range ± 100 steps (up to ± 1.5 mA)
Compliance Voltage ± 8.5 V

Miniaturized Front Ends for Behaving Small Animals

pico-penny

Pico 16+Stim

  • 0.8 g
  • 13.2 mm x 11.7 mm x 3.5 mm
  • Integrated stimulation in the smallest headstage available

Pico 32

  • 1.1 g
  • 15.0 mm x 13.8 mm x 3.5 mm

Pico 32+Stim

  • 2.2 g
  • 23.8 mm x 21.5 mm x 3.5 mm

Chronic experiments made easy

Using the same proprietary ASIC technology as our Nano and Micro line, but redesigned for behaving small animals.

Integrated stimulation and fast-settle technology now allows you to simultaneously stimulate and record in the smallest behaving animals such as mice and songbirds.

Ultra-lightweight boards, and a new super light and flexible cable provides the same high signal quality, but with much less mass and volume.

Digitizing front ends makes the signal immune to movement artifacts, and reduces the conductor count to allow compatibility with smaller commutators for lower costs and reduced drag.

Primary Use Cases

  • Chronic recording in small animals
  • Stimulation
  • Single/multi-unit activity
  • LFPs
  • ECoG/EEG

Specifications

Recording
Resolution 16-bit – 0.125, 0.25, or 0.5 μV/bit (programmable)
Input Range ± 4, 8, or 12 mV (set by resolution)
Sampling Frequency 30 ksps
Hardware Filtering 0.1 – 100 Hz HPF (programmable), 7.5 kHz LPF
Impedance Measurement 10 kΩ to 1.0 MΩ
Input – Referred Noise < 2.1 μVrms
Recording Recovery Post Stimulation < 1 ms
Current-Controlled Stimulation
Resolution 1, 2, 5, 10, or 20 μA/step (programmable)
Stimulation Range ± 100 steps (up to ± 1.5 mA)
Compliance Voltage ± 8.5 V

Bipolar EMG Front Ends

EMG

Designed specifically for for recording from muscle.

  • 24-bit digitization for precise recording over a wide dynamic range
  • 16 differential pairs
  • Designed for bipolar EMG recording experiments
  • 52 mm x 36 mm x 4.75 mm
  • 13.5 g
emg

Specifications

Recording – Bipolar
Resolution 24-bit (0.022 μV/bit)
Input Range ± 150 mV
Sampling Frequency 2 or 7.5 ksps
Hardware Filtering 1.5 kHz
Input – Referred Noise < 1.0 μVrms

Primary Use Cases

  • True-Differential EMG

EEG & Monopolar EMG Front Ends

Surf S2

Compatible with both low and high impedance electrodes

  • Additional ESD protection for surface electrode recordings (EEG)
  • 32-channel, single selectable reference
  • 40 mm x 32 mm x 4.75 mm
  • 9 g
  • Ideal for EEG and monopolar EMG recording experiments
surfs2

Specifications

Recording – Single Selectable Reference
Resolution 16-bit – 0.125, 0.25, or 0.5 μV/bit (programmable)
Input Range ± 4, 8, or 12 mV (set by resolution)
Sampling Frequency 30 ksps
Hardware Filtering 0.1-100 Hz HPF (programmable), 7.5 kHz LPF
Impedance Measurement 10 kΩ to 1.0 MΩ electrodes
Input – Referred Noise < 2.1 μVrms

Primary Use Cases

  • EEG
  • Single-ended EMG

Implantable Front Ends

Introducing the Link

Neuroscience Inside

Ripple Neuro’s Grapevine Link is a family of fully-implantable devices for neuroscience research and translational applications in animal models.

With the Grapevine Link, researchers can conduct long-term recording or stimulation protocols without percutaneous wires, and attach custom electrodes to match specific experimental requirements. Currently, the LINK comes in a 32-channel recording variant. 16 and 64 channel stimulation variants will be available soon. The Link system requires a Grapevine processor and an external driver to power and communicate with the implant.

Features

  • Epoxy-coating for multi-month experiments or ceramic enclosure for multi-year implantation
  • Optional magnetic coupling component for alignment with external transceiver
  • Compatible with all Grapevine Neural Interface system components
link

Specifications

Link-R 32

Channel Count 32
Resolution (programmable) 12-bit (0.125, 0.25 or 0.5 µV/bit)
Input Range (set by resolution) ± 4, 8, or 12 mV
Sampling Frequency 2 ksps
Input – Referred Noise < 2.1 μVrms

Link-S 16 & 64

Coming Soon

Channel Count 16 / 64
Compliance Voltage ± 8.5 V
Max Frequency 15 kHz
Min Pulse Width 1 µs
Current Step Size 0.5 µA
Max Current Amplitude 10 mA (16ch) / 2.5 mA (64ch)

Primary Use Cases

  • EMG
  • LFP
  • Neuromodulation

ECoG+Stim Front End

Integrated Recording and High-Current Stimulation

The ECoG+Stim Front End is an integrated digital amplifier and high-current stimulator ideal for cortical, deep brain, or peripheral nerve applications. As part of the Grapevine Neural Interface System, the ECoG+Stim connects to a Grapevine processor to read signals and control stimulation. A single Grapevine Processor can run multiple ECoG+Stim Front Ends to support higher channel count applications

human-ecog-stim

Features

  • Compatible with macro and microelectrodes
  • 1.5mm touchproof connector interface
  • Constant current and constant voltage output modes
  • One selectable stimulation channel (switch time < 1ms)
  • Monopolar or bipolar waveforms
  • Programmatic control of waveforms and train parameters

Primary Use Cases

  • Stimulation
  • LFP
  • ECoG
  • Single/multi-unit activity

Specifications

Recording
Resolution 24-bit
Inferred Noise <1 µVrms at 2 ksps
Sample Rate 2 ksps and 7.5 ksps
Common Mode Rejection Ratio -110 dB
Input Range Min ± 0.1875 V at a gain of 24
Input Range Max ± 2 V at a gain of 1
Input Impedance 300 MΩ, 150 pF
Current-Controlled Stimulation
Current Range 100 µA – 15 mA
Compliance Voltage ± 9 V to ± 30 V (configurable)
Pulse Width Min 50 µs
Frequency 10 kHz max
Voltage-Controlled Stimulation
Voltage Range ± 3 V to ± 15 V
Pulse Width Min 500 µs
Frequency 1kHz max

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