Applications

The Grapevine Trek surrounded by six research settings: a non-human primate in a primate chair, a tethered mouse, a person walking with an EEG cap, a pig in a jacket, a cat on a platform and a patient in a hospital bed

Brain-Computer Interfaces and Neuroprosthetic Control

Designed for unmatched performance in the most challenging environments, Grapevine Processors & Front Ends provide flexible control and pristine data integrity for BCI and Neuroprosthetic applications. Our novel solutions minimize motion artifacts & electromagnetic interference by amplifying and digitizing neural signals at the electrode resulting in unparalleled data quality.

Take full control over recordings, data processing, trigger output, and stimulation in real-time with our extensive MATLAB and Python APIs. Our Analog and Digital I/O modules provide customizable experimental control.

If you require a mobile platform, look no further. The Trek system supports on-board processing and wireless transmission of data, with an optional external battery increasing total wireless time to up to 8 hours.

Illustration: a non-human primate in a primate chair facing a task display, with a Nano2 front end on its head cabled to a Grapevine processor

What researchers say

For studying the brain, going with Ripple is a no brainer. Ripple’s high channel count ephys equipment allows us to record quality signals from multiple brain areas and allows us to modulate activity in one area while observing direct effects in another.

Camilo Libedinsky, PhD National University of Singapore

Closed-Loop Stimulation

Ripple Neuro’s Nano2 and Pico line of Front Ends provide users with a simple yet powerful way of stimulating in response to neural or behavioral activity. Built with Ripple Neuro’s proprietary stimulation ASIC and paired with our Fast-Settle technology for artifact elimination and comprehensive MATLAB and Python APIs for real time control, our systems provide unparalleled flexibility in applications where closed-loop stimulation is critical for answering scientific questions. Unlike many commercially available products, our solutions are not limited to simple waveforms. Stimulation parameters can be updated every 33 µs, making truly arbitrary waveforms possible.

If you require a mobile platform, look no further. The Trek system supports on-board processing and wireless transmission of data, with an optional external battery increasing total wireless time to up to 8 hours. Our “Code-on-the-Box” software module allows users to run custom code on the processor and save directly to your Grapevine system without the need for a tethered computer.

Illustration: a non-human primate performing a task at a display, with a Nano2+Stim front end on its head; arrows show recording to a Grapevine processor and stimulation back

What researchers say

Our research focuses on the neural basis of decision-making. Ripple’s versatile hardware allows us to observe and manipulate individual decisions as they are unfolding. The ability to record from and stimulate networks of neurons gives us a snapshot of the neural information available to guide each action.

Marlene Cohen, PhD University of Pittsburgh

Ripple’s flexibility and ease-of-use enables a wide-array of applications for recording and stimulation in the peripheral nervous system. Its software versatility allows convenient third-party system integration and flexible programming of adaptive closed-loop systems. This helps drive our projects towards long-term functionality and clinical translation.

Tim Bruns, PhD University of Michigan

Implantable Technologies

Over the last decade, Ripple Neuro has been developing and manufacturing implantable neurotechnology. Our Link R-32 device allows you to record EMG and LFP signals without an implanted battery or percutaneous leads. Enable safer experiments by decreasing animal handling and reducing electrode exposure. Long duration experiments without the worry of infection or rejection are now a reality.

The external transceiver is magnetically coupled with the implanted receiver, inductively powering the implant and allowing for state-of-the-art wireless data telemetry across the skin. Our lead customization kit gives you the flexibility to utilize electrodes of your choosing to best address your workflow demands. Pair with other Ripple Neuro Front Ends to perform multimodal experiments, such as EMG modulated stimulation.

Illustration: a pig wearing a jacket that holds a Grapevine processor, with an implanted device and its leads shown in a close-up

What researchers say

We implanted the EMG telemetry system using custom-made patch electrodes. The entire system worked well with clean signals that have lasted years.

Andy Schwartz, PhD University of Pittsburgh

Acute and Head-Fixed

Providing integrated stimulation and recording on all channels in the smallest commercially available Front End, our Pico Front End line coupled with a Trek processor brings revolutionary solutions for rodent and small animal electrophysiology. Easily synchronize visual displays, treadmills or track balls, optogenetic stimulators, or other devices using the integrated Analog and Digital I/O modules.

Independent grounds enable recording from multiple animals simultaneously for higher throughput. Our Trellis software suite comes standard with real time spike detection and sorting algorithms. Need more sophisticated experimental control? No Problem! Our comprehensive MATLAB and Python APIs give users unparalleled control of recordings, data processing, trigger output, and stimulation in real-time.

Our probe agnostic acquisition systems give users the freedom to choose electrode technology that matches their scientific questions. Our Omnetics terminated Front Ends allow for compatibility with many 3rd party electrode technologies.

Illustration: a head-fixed mouse in a stereotaxic frame, with a probe cabled to a Grapevine processor

Awake Behaving Small Animals

Designed specifically for freely behaving rodents and small animals, our ultra-lightweight Pico Front Ends provide researchers with the flexibility to simultaneously record and stimulate in a high-density configuration. Pico Front Ends build on the versatility of the Trek processor while incorporating flexible commutator and USB camera synchronization solutions, making complex behavioral experiments easy for both the subject and the researcher.

Our small form-factor Pico Front Ends digitize the signal right on the head of the animal, making the signal immune to artifacts from a swinging cable and other sources of noise. Minimize weight with Front Ends weighing less than 0.8g, and with an extremely light and flexible detachable cable.

Whether you need a commutator that is exceptionally small and light-weight or something with a little heft, we've got you covered. With active and passive commutator options, Ripple is prepared to help service your needs across a variety of task conditions and animal models. We also offer a commutator with a fiber-optic rotary joint, allowing for integration of high-quality recording, electrical stimulation, and optogenetic stimulation.

In addition to connecting multiple inexpensive USB cameras to allow time-stamped video recordings from multiple vantage points, our Trellis software suite comes standard with real time spike detection and sorting algorithms. Our comprehensive MATLAB and Python APIs give users unparalleled control of recordings, data processing, trigger output, and stimulation in real-time.

We understand that behavioral experiments require an extensive set of tools. Ripple Neuro partners with companies that specialize in the various components that make your experiments complete. For more complex sorting offline, our data structure ports directly into several 3rd party sorting software suites. If robust positional tracking or behavioral tracking is needed, we are partnered with Stoelting, the gold standard in behavioral tracking software, to provide integration with ANY-maze.

Illustration: a mouse moving freely in an arena, tethered by a cable to a Grapevine processor

Planning a study?

Our team can help you configure the right Grapevine Trek system for your research.